Alcohol and the risk of dementia

An increasing number of cohort studies from different countries continue to be published. The results are heterogeneous concerning light to moderate consumption, while there is can alcohol cause dementia a consensus regarding high consumption and elevated dementia risk (see Table 2). In summary, while a number of studies have reported experimental findings to explain risk reduction through alcohol consumption for vascular dementia, data regarding the impact of alcohol on Alzheimer´s pathophysiology is more contradictory. Sometimes, nutritional supplementation can help prevent the progression of this type of dementia. Additionally, stopping alcohol use is a key factor in preventing additional damage that causes worsening of alcoholic dementia.

Search form

It can be dangerous to stop alcohol abruptly, and it’s safer to go through alcohol detoxification under medical supervision. Importantly, the genetic analyses suggested that clinical factors such as low insulin levels, depression and alcohol use disorder were causally linked to neuropathic pain. This highlights the importance of measuring insulin secretion and assessing mental health in people with diabetes as factors linked to the severity of neuropathic pain. Due to the limited number of studies included in our meta-analyses, we did not assess publication bias by funnel plots; instead we used Egger test, and even though it was statistically non-significant in the majority of cases, we applied the trim-and-fill method to examine the robustness of our findings. We used random-effect meta-analysis to consider the heterogeneity of the studies, even though I2 was not considerable in all analyses (table 3).

Table 1.

Instead, focus on maintaining a healthy lifestyle overall—that includes eating a healthy diet, staying physically active, and maintaining social connections to support brain health as you age. The Food and Drug Administration advises against consuming more than 400 milligrams of caffeine a day—this is roughly two to three 12-ounce cups of coffee. Too much caffeine can lead to serious health problems, including high blood pressure, heart palpitations, increased heart rate, anxiety, digestive issues, dehydration, and sleep issues. “As clinicians, we may recommend changes to caffeine consumption in the setting of anxiety or insomnia, but those recommendations are not based on dementia risk,” Skylar-Scott said. It’s also important to note that the study simply found an association between higher caffeine consumption and lower incidence of memory loss—caffeine may not be the cause.

Alcohol Use Disorder and Dementia: A Review

Long-term alcohol use may lead to Alzheimer’s disease (AD), a type of dementia that affects more than six million Americans. And although the likelihood of having dementia also increases with age, it is not a typical part of aging. Excessive alcohol use may put a person at risk of developing certain health problems relating to the brain. “Alcoholic dementia” is an older term commonly used to describe the medical condition now known as alcohol-related dementia or alcohol-induced major neurocognitive disorder.

• These issues are addressed in this review with the aim to suggest the real risk of alcohol for developing or preventing AD.
• However, relating moderate alcohol consumption with health benefits should not come without question since there are many other issues to consider.
• The first part of treatment for alcohol-related dementia aims to help you stop drinking alcohol.
• There’s a link between type 2 diabetes and dementia, with research suggesting that people with type 2 diabetes have a 50 percent higher risk of developing dementia.
• JR wrote a first draft of the paper, and all authors participated in revising the draft to its current form and approved the final version.

This research joins a growing body of work suggesting that moderate drinking may have positive mental effects. We also used the 1-14 and 15+ groupings to define mild-moderate and heavy drinking. Finally, we additionally adjusted for occupational type, smoking status, ApoE genotype, as well as the alcohol groupings based on the data from the first visit only. The Predictors Study inclusion criteria, exclusion criteria and evaluation procedures are described elsewhere 18, 19.

Data Availability Statement

JR wrote a first draft of the paper, and all authors participated in revising the draft to its current form and approved the final version. The observational epidemiological studies underlying the reviews listed in Table 1 were limited because the majority of the studies were restricted to older populations (that is, late adulthood). Note that alcohol-related dementia is sometimes confused with Wernicke-Korsakoff syndrome.

The UK guidelines suggest an alcohol threshold of 14 units/week but many countries use a much higher threshold to define excessive consumption.48 The present study encourages the use of a lower threshold of alcohol consumption in such guidelines, applicable over the adult life course, in order to promote cognitive health. Results for dementia from the modified Fine and Gray model that accounts for competing risks of mortality were similar to those in the main analysis (table 4). Appendix figure S4 shows the shape of the association between alcohol consumption in midlife and risk of dementia to be unaffected by the exclusion of the large group of abstainers from the analysis. Regardless of type of alcohol consumed, the risk of dementia increased linearly, starting around 14 units/week (appendix figure S5).

Alcohol Effects on the Central Nervous System

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by dense deposition of amyloid-β (Aβ) protein in the brain, failure of the memory and dementia. At present, there is no cure for AD and current treatments only provide a temporary reduction of symptoms. Thus, there is a need for effective preventive/curative strategic approaches. Accordingly, epidemiological studies have reported a reduction in the prevalence of AD in individuals ingesting low amounts of alcohol, while a moderate consumption of ethanol may protect against Aβ. These data are conflicting with other observations that assigned detrimental effects of heavy alcohol use on brain function, which are apparently similar to those observed in AD.

3. Selection criteria

Experts believe the possibility of an inexperienced drinker drinking to excess outweighs the potential benefits. “We hypothesized that alcohol would play some role, but I don’t think anyone expected the size of the effect to be so large,” said lead author Dr. Jürgen Rehm. Adjusted for demographics (age, gender, race, years of education) and baseline cognitive score. Demographic information (age, gender, ethnicity and years of education) and mMMSE score were obtained at the initial visit 19. Patients were categorized into 2 groups, based on having at least one ApoE ε4 allele and those possessing none (as the reference). The local institutional review boards authorized this study and all subjects provided written informed consent.